Gray matter abnormalities in Internet addiction

Yan Zhou, Fu-chun Lin, Ya-song Du, Ling-di Qin, Zhi-min Zhao, Jian-rong Xu and Hao Lei (November 2009) European Journal of Radiology, In Press, Corrected Proof, Available online 18 November 2009

Gray matter abnormalities in Internet addiction: A voxel-based morphometry study

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Abstract

Background

This study aims to investigate brain gray matter density (GMD) changes in adolescents with Internet addiction (IA) using voxel-based morphometry (VBM) analysis on high-resolution T1-weighted structural magnetic resonance images.

Methods

Eighteen IA adolescents and 15 age- and gender-matched healthy controls took part in this study. High-resolution T1-weighted magnetic resonance imaging scans were performed on the two groups. VBM analysis was used to compare the GMD between the two groups.

Results

Compared with healthy controls, IA adolescents had lower GMD in the left anterior cingulate cortex, left posterior cingulate cortex, left insula, and left lingual gyrus.

Conclusions

Our findings suggested that brain structural changes were present in IA adolescents, and this finding may provide a new insight into the pathogenesis of IA.

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